Introducing Lifespan
The speed of aging accelerates over time.
Lifespan slows it down.
Lifespan is a cutting-edge digital health clinic offering a scientifically-backed longevity protocol of rapamycin to combat aging. Sign up now for exclusive pre-launch pricing before our official February 2025 debut.Join us in the fight against aging.
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Lifespan
Longevity Benefits of Rapamycin
Rapamycin stands out as a pioneering medication that inhibits the formation of senescent cells—aged, dysfunctional cells that accumulate over time—potentially slowing aging and enhancing cellular performance across your body. While it has been an FDA-approved drug for a long time, many are now using it off-label for longevity purposes. Here are some reasons why:
Stimulate Autophagy: Activate your cells' self-cleaning mechanism, promoting the removal of dysfunctional cellular components and enhancing organelle turnover.
Tamp Down Senescence: Selectively inhibit mTORC1, a key component of the mTOR pathway, to mitigate cellular senescence and potentially slow age-related tissue dysfunction.
Reduce Inflammation: Decrease senescence-associated secretory phenotype (SASP), potentially alleviating chronic low-grade inflammation characteristic of aging.
Enhance the Immune System: Modulate immunosenescence, potentially improving T-cell function and bolstering your body's adaptive immune responses.
Improve Cognitive Performance: Support neuroplasticity and synaptic function, potentially enhancing memory consolidation and cognitive resilience.
Example Impact on Biological Age:
Slow down aging
Become an Early Lifespan Adopter
Enroll now for an exclusive 40% early adopter discount towards your first three months of the rapamycin protocol.
Pharmaceutical grade generic rapamycin, encapsulated for enhanced absorption
Taken once weekly as part of prescriber-guided titration
Subscription includes initial & ongoing blood work
Shipped monthly
Sourced from a certified, US-based pharmacy
Free shipping
Pause or cancel your plan at any time
Starting at $125/month $75/month.*
Please note that this is a pre-launch, one-time payment to reserve your exclusive early adopter pricing. Your payment will be credited against any future services or offerings that you buy from Lifespan. At the time of Lifespan's launch, we will direct you to complete a brief intake survey and one of our license physicians will determine whether you are eligible to enroll in our rapamycin protocol. If you are deemed ineligible, you will receive a full refund. You can also request a refund at any time prior to Lifespan's launch.
*Discounted price shown available for first three months of the protocol as part of an early adopter's discount program. You have the option to request a full refund at any time before we ship your first order of rapamycin. Medication is offered as a subscription service which you can cancel at any time. Medication is only prescribed if enrolled in the protocol.Prescription products require evaluation with a licensed medical professional who will determine if a prescription is appropriate. Not all who apply will be eligible. See below for important safety information. Benefits outlined by Lifespan are based on 3rd party studies.
Your Longevity Protocol
How Lifespan Works
Explore the most promising longevity therapy today, with ongoing monitoring and blood work included with your rapamycin prescription.
1. Sign up
Manage treatment online with a secure, HIPAA-compliant login.Our licensed medical providers will help assess via an online consultation whether our rapamycin protocol is right for you.
2. Get Free Delivery
Medication filled by U.S.-based pharmacies, with free shipping to your door.We will seamlessly facilitate any lab work deemed necessary by your provider.
3. Receive Ongoing Clinician Support
Our medical providers are licensed across the country and can provide ongoing support during your protocol. Pause or cancel your plan at any time.
Frequently Asked Questions
How does the process work?
On launch day, which is anticipated in February 2025, you will receive an automated email from Lifespan allowing you to set up your account and proceed with your consultation.After you complete your online health evaluation, a US-based physician will review your information and recommend a treatment plan. Once the physician approves a prescription, we will ship your medication. If you are deemed ineligible to participate by the physician, you will receive a full refund.Your blood work may be required to determine your continued eligibility.
Why is Lifespan accepting customers pre-launch?
Ahead of Lifespan's official launch in February, we are in the final stages of building our platform alongside our licensed physicians, our licensed pharmacy partners, and our developers. Understanding customer interest ahead of launch allows us to be better prepared to meet your needs quickly and efficiently. Thank you for your patience as we finalize our LegitScript certification, perform final testing on our HIPAA-compliant platform, and ensure seamless integration with our pharmacy partners. We look forward to being a meaningful part in your personal longevity journey!
What will be included in my plan?
Your health protocol includes continued access to physicians, pharmacies, and labs as needed, as well as your prescription(s).
Is this covered by insurance?
Because the use of rapamycin to treat cellular senescence is an off-label use of the medication, we are unable to bill any insurance plan. However, you may want to contact your insurance provider directly to see if you are eligible to file a claim.
Does Lifespan test medications for purity and bioavailability?
At Lifespan, we are committed to ensuring the effectiveness of the medications we prescribe. This commitment extends to addressing the challenges of bioavailability, which can notably impact the usage and efficiency of certain drugs, including rapamycin. To tackle this, we employ a robust testing program to select the formulations and brands of rapamycin that offer the best absorption levels.We believe in personalized care and thus, offer our patients the option to test their individual rapamycin levels. This enables us to understand each patient's unique absorption profile of the medication, taking into account the variability of their biology. This approach ensures that our patients receive the most effective therapeutic regimen tailored to their individual needs.
Where do you ship?
We can ship to all 50 states.
What payment methods do you accept?
We currently accept major credit cards such as Mastercard, Visa, and American Express. We also accept Apple Pay, Google Pay, and Link. At the present time, we cannot accept HSA cards.
How can I request a refund if I change my mind?
While we would love to support your longevity efforts with our rapamycin protocol, we understand that you may change your mind ahead of our official launch. If you would like to request a refund at any time before launch, you can send a simple email to [email protected].
What is included in the rapamycin protocol?
The rapamycin protocol is a fully comprehensive and personalized treatment plan guided by your Lifespan physician, medical team, and the Lifespan Research Review team.Medical review by a US-based functional medicine doctor. Our US functional medicine doctors analyze your biomarkers and clinical data to prescribe personalized health recommendations. If your doctor deems the medication appropriate for you, you will be prescribed a treatment plan explaining the benefits and what to expect. Your doctor will review and optimize your dosage every 30 days.Prescriptions delivered to your door. Our US-based pharmacies, which are LegitScript-certified, handle the direct shipment of your medication to your doorstep. We prioritize selecting medications with the highest bioavailability to maximize their effectiveness. Additionally, we provide patients with the option to test the concentrations of rapamycin in their bloodstream, ensuring that the treatment is suitable and personalized for their specific needs.Regular Lab Testing. We will optimize your dosing regimen by taking baseline blood draw to monitor biomarkers key to longevity and follow up with subsequent lab testing to see how your treatment is progressing and further optimize your treatment plan.The Lifespan Research Review Team. Lifespan collaborates closely with esteemed researchers to conduct a meticulous meta-analysis of the most cutting-edge studies in the field of longevity medicine. This ensures that our protocol is based on the latest scientific findings. They are available to address any health-related inquiries you may have and offer an in-depth analysis of the most recent research pertaining to your specific concerns. This personalized approach allows us to provide you with tailored information and insights to support your well-being effectively.
How frequently do I take my rapamycin dose on the longevity protocol?
Upon thorough medical review and screening, should you be deemed suitable for the Lifespan rapamycin protocol, your administration of Rapamycin will occur just once a week. For instance, should your current weekly dosage be 5mg, and you're given 1mg pills, you'll consume all five pills on a single day, as opposed to distributing them over the week. You'll then rest until the next week.The reason for this methodology stems from the cyclical nature of the benefits rapamycin offers for anti-aging. Unlike transplant patients who take rapamycin daily, the longevity benefits are drawn from the intermittent inhibition of mTOR. The therapeutic benefit of rapamycin is derived from pulsated inhibition of mTOR, avoiding continuous inhibition. This approach prevents bloodstream concentrations of rapamycin that could inhibit mTOR-Complex 2, leading to immune suppression, which we aim to evade.By adhering to a weekly dosage, adjusted according to your unique biomarkers and phenotype, we sidestep the immunosuppressive side effects of rapamycin. We strive to administer rapamycin in a manner that leverages the mTOR inhibitory benefits, such as stimulating autophagy, in cycles, and then returning to baseline mTOR activity.
What is the dose of the Lifespan rapamycin protocol?
At Lifespan, we harness the power of advanced technology and your unique biomarkers to craft a tailored rapamycin dosage plan just for you. Typically, we will initiate a patient's treatment with a weekly dose of 2-3mg, carefully escalating this over time to reach the optimum dosage, which generally lies between 5 to 8mg per week. Please note, the provision of medication is strictly contingent upon a comprehensive medical review and initial screening process.
Why do some sources mention a risk of cancer associated with rapamycin?
The risk of cancer is related to daily dosing for transplant patients, whereas our approach involves intermittent dosing every 7 days to avoid immune suppression. This distinction has varying implications for cancer. Rapamycin inhibits mTOR, exhibiting anti-cancer properties by preventing cell proliferation and inflammatory conditions conducive to cancer.There are two complexes of the mTOR pathway: mTORC1 and mTORC2. Daily dosing may suppress the immune system, while our low-dose cyclical dosing enhances immune function, potentially contributing to rapamycin's anti-cancer benefits. Inhibiting mTORC1, as low-dose cyclical dosing rapamycin does, has been shown to extend lifespan in various animal models by promoting autophagy, reducing inflammation, and slowing the aging process. Consistent, daily use of rapamycin will also inhibit mTORC2 and can bring on unwanted side effects.Our low-dose, cyclical dosing strategy harnesses the longevity-promoting effects of mTORC1 while avoiding the negative side effects linked to mTORC2 suppression.
Research & Clinical Trials
Explore the scientific studies and articles listed below to learn the potential geroprotective benefits that rapamycin offers and why many people take it off-label for longevity purposes.
1. Rapamycin extends life- and health span because it slows aging
2. Evaluation of off-label rapamycin use to promote healthspan in 333 adults
3. Blazing a trail for the clinical use of rapamycin as a geroprotecTOR
4. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
5. Rapamycin: One drug, many effects
6. mTOR Signaling in Growth, Metabolism, and Disease
7. Rapamycin and Alzheimer’s disease: Time for a clinical trial?
12. Ovarian Aging: Mechanisms and Clinical Consequences
13. mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
15. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
16. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
17. mTOR inhibition improves immune function in the elderly
19. The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
Patient Safety
Important safety information and common side effects
By completing a free visit, you have the opportunity to consult with an Lifespan prescriber about your health, medical history, and lifestyle. Your prescriber will use this information to evaluate your overall health and, if appropriate, prescribe medication in tandem with monitoring.If approved, you will receive a doctor-guided monthly titration plan to gradually introduce rapamycin to your body, so you can enjoy minimal side effects and maximal benefits. Your titration plan is determined based on your unique medical history; it may differ from standard titration plan, listed above. Always follow the instructions of your provider when titrating with rapamycin. Your titration will be clearly listed on your prescription bottle as a reminder.You are required to complete baseline blood work before your prescriber considers whether rapamycin is right for you. Patients who do not complete their baseline blood work will not be considered for a rapamycin prescription. You must also complete ongoing blood work, report any benefits or side effects, and fill out periodic questionnaires to determine your continued eligibility. Failure to comply with blood work or other reporting requirements may result in your prescription being suspended or canceled.Most common rapamycin side effectsRapamycin is generally a well-tolerated medication and most often exhibits the following minor side effects:
+ Mouth ulcers (stomatitis)
+ Nausea
+ DiarrheaMost side effects are mild and go away on their own within a week or two. If you notice a persistent infection, such as a mouth ulcer that won’t go away as quickly as normal, please consult your healthcare provider.Please review the Mayo Clinic’s full list of possible side effects_ before getting started with a free visit.Other important safety informationAs a substrate for p-glycoprotein and cytochrome P-450 3A4, Rapamycin may have certain interactions with other drugs or supplements that act on these proteins. These include cyclosporine, rifampin, ketoconazole, cidofovir, ritonavir, mifepristone, posaconazole, fluconazole, and grapefruit juice.Before taking rapamycin, be sure to review the full list of potential drug interactions and talk to your healthcare provider about any medications you are currently taking.Do not take rapamycin if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. Do not take rapamycin if you are scheduled to undergo major surgery, chemotherapy or immunosuppressant therapy for a transplant within the next 6 months; have a chronic infection (such as HIV/AIDS, Lyme disease, etc.), have any primary or secondary immune dysfunction or deficiency, and/or any allergy to rapamycin or any of its ingredients.While rare, it is possible that some who take rapamycin may potentially become more susceptible to skin and/or lung infections. However, this is still being investigated and is not a proven risk associated with rapamycin when taken at the frequency and doses prescribed at Lifespan. If, at any time, you feel you are developing a troubling skin or lung infection, seek care at a local urgent care center, contact your PCP, or use an acute-care telemedicine service as soon as possible. Be sure to report the details to our medical team when you are able.Note: The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Stay ahead of aging.
Join Lifespan.
Take control of your longevity today. Sign up at Lifespan and receive an exclusive pre-launch offer of $75/month (40% discount) for your first three months of the Lifespan Rapamycin Protocol.
Privacy Policy
Information We Collect
We collect personal information including names, billing addresses, and payment information when you sign up for Lifespan's services.
How We Use Your Information
The information we collect is used solely for the purpose of signing up customers interested in Lifespan's services ahead of our official launch.
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Data Sharing
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Data Security
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Changes to This Policy
We may update this privacy policy from time to time. Any changes will be posted on this page.
Contact Us
If you have any questions about this privacy policy, please contact us at [email protected].
Last updated: October 15, 2024
$75.00
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We will notify you via email on launch day when you are eligible to complete your intake form and begin your longevity journey with Lifespan.Refunds can be requested prior to launch by emailing [email protected].